Abstract: [ Abstract ] Objective Toobservetheeffectsofdifferentconcentrationsofadrenalinin
perfusionsolutionon mydriasisandthecornealendothelium inphacoemulsificationcataract
surgeryandtodiscussclinicalrationalconcentration.Methods Onehundredandfivesimple
senilecataractpatients ( 120eyes ) weredividedrandomlyintoA , BandCgroups ( eachgroupwith
40patients ) .0.1 mL , 0.2 mLand0.5 mL1‰ adrenalin wereaddedinto500 mLperfusion
solution.Phacoemulsificationandintraocularlensimplantationwereperformedinallpatients.
Beforesurgeryand1weekaftersurgery , cornealendothelialdensity , thepercentageofhexagonal
cellsand variablecoefficient were detected by cornealendothelialcellinstrument without
touching.Results Thepupildiametersinthe3groupsduringoperationwereallgreaterthanor
equaltothoseofpreoperation.Thedifferencesofthepreoperativecornealendothelialcell
density , thepercentageofhexagonalandcellsvariablecoefficientamongthe3groupswerenot
statisticallysignificant ( P >0.05 ) .Thepostoperativecelldensityandthepercentageofhexagonal
cellswerelowerthanthosebeforeoperation.TherewassignificantdifferenceofgroupBand
groupCcomparedtothatbeforeoperationrespectively ( P <0.05 ) andthedifferenceofgroupA
wasnotstatisticallysignificant ( P >0.05 ) .Therewasnostatisticallysignificantdifferenceamong
thethreegroups ( P >0.05 ) .Thevariablecoefficientwashigherthanthatbeforeoperationin groupC ( P <0.05 ) .Therewasnostatisticallysignificantdifferenceofvariablecoefficientin
groupAandgroupBcomparedtothatbeforeoperation ( P >0.05 ) .Thevariablecoefficientof
groupCwashigherthanthatofgroupA ( P <0.05 ) .Conclusion Theeffectiveandthelowest
adrenalinconcentration ( 0.1mL1‰adrenalinin500mLperfusionsolution ) shouldbeappliedin
phacoemulsificationinconsiderationofthepotentialadrenalintoxicity.

Key words: phacoemulsification , epinephrine , pupil , endothelium, corneal