Analysis of common deafness genes in 60 patients with cochlear implantation

doi:10.3969/j.issn.10073205.2016.11.014

Abstract

Abstract: [
Abstract ] Objective Toanalyzetheincidenceofhereditaryhearinglossinpatientswith
cochlearimplantation.Methods Usingpolymerasechainreactionandrestrictionenzymemethod ,
themutationsof235delC GJB2 , IVS7-2A>G PDSand mitochondrial12sRNA A1555G DAN
weredetectedin60patientswithcochlearhearingloss.Results Atotalof33patientswith
geneticmutationweredetectedin60cochlearimplantationpatients , andthetotalmutationrate
was55.0% , including : 235delC homozygous mutationin 6 cases ( 10.0% ), 7 cases with
heterozygous mutation ( 11.7% ); PDS genehomozygousIVS7-2A > G mutationin 6 cases
(
10.0% ), heterozygousmutationin12cases ( 20.0% ); DNA mitochondrial12sRNA A1555G
mutationpositivefor2cases ( 3.3% ) .Conclusion Themaincausesofthediseasearegenetic
factors , IVS7-2A>GgenePDS , followedbythe235delCgeneGJB2sitemutation.Somepatients
aremitochondrial12sRNAA1555GDANsitemutation.

Key words: deafness, cochlear implantation, genes, mutation

ZHANG Xuemei1, ZHAO Ning1, DONG Mei2, LIU Hui1, MAO Yinan3, ZANG Wen1. Analysis of common deafness genes in 60 patients with cochlear implantation[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2016.11.014.

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Analysis of common deafness genes in 60 patients with cochlear implantation

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