Abstract: Abstract］Objective〖HTSS〗〓To investigate the relationship of carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1) and vascular endothelial growth factors (VEGF) expression with angiogenesis in mucoepidermoid carcinoma(MEC) of salivary glands.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The expression of CEACAM1 and VEGF was detected with immunohistochemcal method streptavidinperosidase (SP) in 70 cases of MEC tissues，and 20 cases of normal salivary gland，the microvessel density(MVD) was recorded under optical microscope.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive expressions of CEACAM1 protein (34.3% vs 70.0%) was lower in MEC group than those in normal salivary gland group(P＜005)，the positive expressions of  VEGF protein (71.4% vs10.0%) was higher in MEC group than those in  normal salivary gland group(P＜005). In MEC group，the positive expressions of CEACAM1 protein in pathological grade levelⅢ patients were lower than those in pathological grade level Ⅰ+Ⅱ patients(P＜005)，the positive expressions of CEACAM1 protein in TNM stage Ⅲ+Ⅳpatients were lower than those in TNM stageⅠ+Ⅱ patients(P＜005)，the positive expressions of CEACAM1 protein in patients with lymph node metastasis were lower than that in patients without lymph node metastasis(P＜005). The positive expressions of VEGF protein and MVD in pathological grade level Ⅲpatients were higher than those in pathological grade level Ⅰ+Ⅱpatients(P＜005)，the positive expressions of VEGF protein and MVD in TNM stage Ⅲ+Ⅳ patients were higher than those in TNM stage Ⅰ+Ⅱpatients(P＜005)，the positive expressions of VEGF protein and MVD in patients with lymph node metastasis were higher than that in patients without lymph node metastasis(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Downregulationg of CEACAM1 in MEC of salivary glands may play a role in angiogenesis through increasing the expression of VEGF，thus promote tumor invasion and metastasis.

Key words: carcinoma, mucoepidermoid, vascular endothelial growth factors, angiogenesis