Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the effect of the Resveratrol on tumor necrosis factor alpha(TNFα) and interleukin 6(IL6) levels in rats with ischemic injury.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thirtysix rats were divided into group A, group B and group C, with 12 rats in each group. The group A was the control group without treatment, and the group B and the group C were given resveratrol 25 mg/kg and resveratrol 50 mg/kg. The doubleantibody sandwich enzyme linked immunosorbent assay method was used to determine TNFα and IL6 levels in the brain tissue homogenate，and to detect the cell proliferation inhibition of resveratrol.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The TNFα and IL6 levels in group B and group C were significantly lower than those in group A, the TNFα and IL6 levels in group C were lower than those in group B, the differences were significant(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Resveratrol inhibits brain inflammation and improves cerebral ischemia by inhibiting the levels of TNFα and IL6 in the brain, which is worthy of clinical application.

Key words: brain ischemia； resveratrol； cytokines, rats