Abstract: ［Abstract］ Objective〖HTSS〗〓To evaluate the effect of XueSuSheng granule on different anemia models.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓 In this study, the models of acute hemorrhagic anemia in mice and the anemia model induced by chemotherapeutic drugs in rats were established. The blank control group, the model control group, the test group and the positive drug control group were set up in different disease models. After a period of time of administration, blood samples were collected from different time points after the model was started, and five indexes of white blood cells(WBC), red blood cells(RBC), hemoglobin(Hb), platelets(PLT) and reticulocytes(RET) were measured. A statistical difference was found between the same time points and between different groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓By comparing the XueSuSheng granule group and the model group, the increase of the counts of RBC, Hb and RET had statistical significance(P＜005), but had no statistical significance on WBC and PLT in mice acute hemorrhagic anemia model(P>0.05). The increase of the counts of WBC, RBC, Hb and RET had statistical significance(P<0.05), but had no statistical significance on PLT(P>0.05) in rats chemotherapy anemia model.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓XueSuSheng granule can improve RBC and Hb reduction caused by acute blood loss, and has positive effect on WBC, RBC and Hb reduction by significantly improving bone marrow hematopoietic function.

Key words: anemia； XueSuSheng granule； mice, rats