Abstract: ［Abstract］ Objective〖HTSS〗〓To compare the readhesion prevention effect of artificial cyclic estrogenprogesterone and gonadotrophinreleasing hormone agonist(GnRH) treatment on patients after hysteroscopic operation for moderate to severe intrauterine adhesions, and clinical outcome data from our hospital were analyzed statistically.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and thirtyeight patients including 78 cases of clinically diagnosed as moderate and 60 cases of severe intrauterine adhesions were divided into the experimental group(n=69 cases) and the control group(n=69 cases) randomly. The control group was treated with artificial cycle after hysteroscopy, the experimental group was treated with combined GnRHa. The clinical effects of two groups of patients with menstrual cycle recovery and postoperative recurrence were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There was no significant difference between the 2 groups in volume of uterine cavity(P＜005). The improvement rate of menstruation in the experimental group was better than that of the control group(P＜005);the intrauterine readhesion rate was lower than that of control group(P＜005). After 3 months of operation, the VAS score and CA125 level of the experimental group and the control group were significantly decreased(P＜005), but the results in the experimental group was better than the control group(P＜005). The pregnancy success rate in the experimental group was higher than the control group(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Combined with GnRHa treatment, the effect of artificial cycle therapy is more obvious in female patients with intrauterine adhesions.

Key words: intrauterine adhesion, estrogens; , progestins, pregnancy outcome