Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze the expression and clinical significance of vascular endothelial growth factor（VEGF）, microRNA18a（miR18a） and minichromosome maintenance 7（MCM7） in uterus myoma tissues.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The expression of VEGF, progesterone receptor （PR）, estrogen receptor （ER） and MCM7 of 43 uterus myoma tissues and perimyoma normal tissues were detected by immunohistochemistry,the expression of miR18a were detected by in situ hybridization method.The expression results were compared and analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive rates of  VEGF, PR, ER and MCM7 in uterus myoma tissues were significantly higher than those in perimyoma normal tissues,the positive rates of miR18a was significantly lower than those in perimyoma normal tissues(P＜0.05). The results of Spearman correlation analysis showed,the expression of PR,ER were positively correlated with the expression of VEGF, and MCM7(P＜0.05) were positively correlated with the expression of miR18a(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓There are high expression of VEGF, MCM7 in uterus myoma,the expression of miR18a is low,It is closely related with the occurrence and development of myoma of uterus.

Key words: leiomyoma, vascular endothelial growth aactor, progestins, estrogens