Abstract: ［Abstract］  Objective〖HTSS〗〓To investigate the distribution of Acinetobacter baumannii and its resistance to antimicrobial agents in the second hospital of Hebei Medical University from 2015 to 2016, and to evaluate the clinical value of the infection.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓This surveillance totally collected 2 253 strains of nonrepetitive bacteria, had a bacteria identification and drug sensitivity test determination with Vitek2Compact and had a statistic analysis of data with the software of Whonet 5.6.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓In the two years, 2 253 nonrepeat strains were detected in the whole hospital, and the composition ratio was 14% and 14% in 2015 and 2016 respectively. The detection rate of Acinetobacter baumannii was the third highest in the whole hospital. The detection rate of sputum specimens was 89.5% and 91.6% respectively. The detection rate of blood samples was 2.1% and 2.4%. The detection rate of the sputum specimens and blood samples were 1%, 0.8%, no cases of detection of Acinetobacter baumannii were detected by urine and blood culture. In the two years , Acinetobacter baumannii resistance to polymyxin B, tigecycline, cefoperazone/sulbactam, minocycline were less than 30%, the resistance rate to meraceran  was 83.8%, 76.8%, the resistance rate to imipenem was 67.1%, 64.4%, the majority of antimicrobial agents showed a different degree of decline in drug resistance. From 2015 to 2016, Acinetobacter baumannii in addition to cephalosporins antibiotics and aztreonam blood samples were higher than the rate of sputum drug resistance, other sputum specimens were higher than the resistance rate of blood samples. Among them, the resistance rate of nitrofurantoin, meropenem, imipenem, cefepime, tobramycin and levofloxacin were significantly different, which was statistically significant.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Acinetobacter baumannii infection form is still grim, lower respiratory tract infection also led to the risk of bloodstream infection. Quantitative sputum culture, white blood cell count, procalcitonin, increased Creactive protein were used as a risk factor for bloodstream infection to assess the main inflammatory index.

Key words: Acinetobacter baumannii, lower respiratory tract infection, bloodstream infection, resistance