Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the pathogen distribution of blood samples isolated from secondgrade hospitals in Hebei and their resistance to antibiotics.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Drug resistance data of isolated bacteria of blood sample from secondgrade hospitals during 2016—2017 were analysed by  Whonet 5.6 software according to CLSI 2016.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓A total of 2 909 strains of bacteria were collected by blood culture, of which 1 684 strains were G-strains(57.9%) and 1 225 strains were G+ strains(42.1%). Methicillinresistant S. aureus(MRSA) and coagulasenegative Staphylococcus(MRCNS) accounted for 50.0% and 72.1%, respectively. No staphylococcal strains were found resistant to vancomycin, teicoplanin or linezolid. The resistance rates of E. faecalis and E. faecium to vancomycin were 2.7% and 1.8%, respectively. Both of these two kinds of strain have no resistance to teicoplanin or linezolid. The prevalence of ESBLproducing of E. coli and K. pneumonia were 50.3% and 26.2%, respectively. Resistance rates of E. coli to imipenem and meropenem were 6.1% and 1.0%, respectively. Resistance rates of K. pneumoniae to imipenem and meropenem were 5.7% and 6.2%, respectively. The resistance rates of P. aeruginosa to imipenem and meropenem were both 34.0%. The resistance rates of other antibiotics  for P. aeruginosa were lower than 30.0%. The Resistance rates of A. baumannii strains to imipenem and meropenem were 34.0% and 42.5%.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓It is important to evaluate the pathogenicity of different bacteria for clinical diagnosis and treatment. The pathogens isolated from blood specimens are diverse showing various levels of resistance to common antimicrobial agents. Antibiotics should be prescribed reasonably according to local susceptibility testing data.

Key words: drug resistance, bacterial, antimicrobial drugs; , blood specimen