Abstract: ［Abstract］ ObjectiveTo investigate the changes of blood glucose and blood lipid levels in patients with hyperhomocysteinemia(HHcy). MethodsA retrospective study were performed in 528 cases from hospital of armed police public security fire control team of Tangshan or from Tangshan people′s hospital. On the basis of homocysteine levels, all cases were divided into normal control group(< 15.0 μmol/L), mild increase group(15~30 μmol/L), moderate increase group(＞30~100 μmol/L) and the severe increase group(>100 μmol/L), Blood glucose and blood lipid levels were measured in each group. SPSS 19.0 software were used for statistical processing. The changes of blood glucose and blood lipid levels in patients with homocysteine were compared. ResultsCompared with the normal control group, TC, LDLC level in Hcy mild increase group, in moderate increase group and in the severe increase group were increased significantly. The difference was statistically significant and two two comparison of the differences also have statistical significance(P<005). But there was no significant difference in the level of GLU and HDLC in all the groups(P>005). Linear correlation analysis showed that the change of Hcy concentration was correlated with the GLU, TG, TC, HDLC, LDLC. However, if Logistic regression analysis was performed by using GLU, TG, TC, HDLC, LDLC, Lpa as the independent variables and HHcy as the dependent variable, the results showed that the correlation between HHcy, TG, TC, HDLC, LDLC, Lpa, and GLU was not statistically significant, but was the result of a multifactor action. Independent variables had little effect on HHcy. ConclusionHigh homocysteine levels are affected by multiple factors. The blood glucose and blood lipid levels in the patients were changed, and the changes of serum TC and LDLC levels were the most significant.

Key words: hyperhomocysteinemia, blood glucose, cholesterol