Journal of Hebei Medical University

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Analysis of pathogen distribution and drug resistance in blood samples of different ages from Tertiary hospitals in Hebei province during 2016-2017#br#

  

  1. 1.Hebei Provincial Center for Clinical Laboratory, the Second Hospital of Hebei Medical University，
    Shijiazhuang 050000, China; 2.Department of Clinical Laboratory,the Second Hospital of Hebei
    Medical University, Shijiazhuang 050000, China; 3.Department of Research Center,
    the Forth Hospital of Hebei Medical University, Shijiazhuang 050011, China
  • Online:2019-11-25 Published:2019-11-21

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Abstract: ［Abstract］Objective〖HTSS〗To investigate the pathogen distribution and antimicrobial resistance of the isolates from blood samples from tertiary hospitals in antimicrobial resistance surveillance system of Hebei province.
〖HTH〗〖WTHZ〗Methods〖HTSS〗Clinical isolates from blood specimens were collected during 2016-2017. The data of antimicrobiol resistance were analyzed according to CLSI 2016.
〖HTH〗〖WTHZ〗Results〖HTSS〗A total of 17 815 bacteria including 45.9% Gram-negative strains and 54.1% Gram-positive strains was isolated. Methicillin-resistant staphylococcus aureus(MRSA) and methicillin-resistant coagulase-negative staphylococcus(MRCNS) accounted for 46.3% and 80.0%, respectively. None of staphylococcal strains were found resistant to vancomycin, teicoplanin or linezolid. The resistance rates of E. faecium to vancomycin and teicoplanin were 1.4% and 1.9%, respectively. The resistance rates of E. faecali to vancomycin and teicoplanin were 0.0% and 0.6%, respectively. The resistance rate of E. faecium and E. faecali to linezolid was 1.1% and 0.4%.The prevalence of penicillin-resistant S. pneumoniae isolated was 5.4%. The prevalence of ESBL-producing of E. coli and K. pneumoniae were 65.4% and 43.8%, respectively. Resistance rates of E. coli to imipenem and meropenem were 1.8% and 1.6%, respectively. Resistance rates of K. pneumoniae to imipenem and meropenem were 15.7% and 15.7%, respectively. The resistance rates of P. aeruginosa to all the drugs tested in this study were lower than 30.0%. Resistance rate of A. baumannii strains to cefoperazone-sulbactam was 19.3%. However, the Resistance rates of A. baumannii strains to imipenem and meropenem were much higher up to 60.9%and 53.8%,respectively.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗Gram-negative bacteria are still the main pathogen of bloodstream infections. Isolates from blood specimens are showing various levels of resistance to common antimicrobial agents. Dynamic monitoring of bacterial resistance is of great significance to the rational use of antibiotic.

Key words: blood specimen, bacterial resistance surveillance, antimicrobial agent