Abstract: ［Abstract］Objective〖HTSS〗To evaluate the clinical effect of dexmedetomidine(Dex) in general anesthesia in patients with schizophrenia.
  〖WTHZ〗Methods〖HTSS〗Sixty patients with schizophrenia undergoing elective surgery, American Society of Anesthesiologists（ASA） grade Ⅰ~Ⅱ, had a history of taking antipsychotic drugs for a long time. According to the method of random digital table, the patients in the two groups were randomly divided into two groups: Dex group(n=30) and control group(n=30). The patients in the two groups were operated under general anesthesia with endotracheal intubation. Dex group was injected intravenously with dexmetomide 1.0 ug/kg, 10 min before general anesthesia induction and then continued infusion with 0.4 μg·kg-1·h-1 until the end of the operation, and the control group was infused with saline of the same volume. The mean arterial pressure(mean artery pressure,MAP) was recorded before anesthesia induction(T1), immediately after endotracheal intubation(T2), at the time of skin incision(T3) and at the end of operation(T4). Peripheral venous blood samples were collected before anesthesia induction(T1), during skin incision(T3) and at the end of operation(T4). Cortisol(Cor), high sensitive C-reactive protein(hs-CRP), tumor necrosis factor α(TNF- α), interleukin-6(IL-6) and interleukin-10（IL-10) were measured, and 10 min(T5) after tracheal intubation was evaluated. Ramsay Sedation Score(RSS） and Restlessness Score(RS) at 20 min(T6) after extubation.
  〖WTHZ〗Results〖HTSS〗The level of MAP in Dex group decreased at first and then increased, the level of MAP in NS group increased gradually, and the level of MAP in Dex group was lower than that in NS group. There was significant difference in the interaction between groups, time points and time points. The levels of Cor, hs-CRP, TNF- α and IL-6, IL-10 in Dex group were significantly higher than those in NS group, and the level of IL-10 in Dex group was higher than that in NS group. The RSS of Dex group was higher than that of NS group, and the RS of T5 and T6 group was significantly lower than that of NS group(P＜0.05).
  〖WTHZ〗Conclusion〖HTSS〗Dexmetomide can maintain the perioperative circulation stability of psychotic patients, ensure good sedation during recovery, effectively control the perioperative stress level of patients, reduce the release of immune inflammatory factors, reduce restlessness during postoperative recovery, and ensure that the perioperative mental symptoms of patients are more stable, which is worth popularizing and applying.

Key words: schizophrenia, dexmedetomidine, anesthesia, general