Abstract:

Objective  To explore the effects of the levels of glutamine(Glx) and glutamate(Glu) on the early identification of neurobiochemical abnormalities in high-risk people with schizophrenia through Meta-analysis.

Methods  The literature was retrieved from Chinese and English databases from the establishment to October 31,2020, and the differences of Glx and Glu concentrations in the brain measured by magnetic resonance spectroscopy(MRS) were collected and compared between high-risk group of schizophrenia and the normal control group.

Results  A total of 27 articles, 43 groups of data and a sample size of 3 875 were included. Meta-analysis results showed that the concentration of Glu in the thalamus, dorsolateral prefrontal lobe and temporal lobe in the high-risk group of schizophrenia was lower than that in the normal control group, while no difference in Glx or Glu was found in other brain regions or the whole brain between two groups.

Conclusion  Glu concentration in the thalamus may be a risk marker before the onset of schizophrenia.

Key words: schizophrenia, magnetic resonance spectroscopy； glutamate