Abstract: ［Abstract］Objective〖HTSS〗To investigate the hemodynamic changes of carotid and cerebral arteries in hypertrophic cardiomyopathy(HCM).
Methods〖HTSS〗Totally 40 HCM patients and 25 normal controls were enrolled. All of them received echocardiography, carotid and cerebral arteries color Doppler ultrasound. Echocardiographic parameters included maximal left ventricular wall thickness(MLVWT), left ventricular end-diastolic diameter(LVEDD), left ventricular end-diastolic and systolic volume(LVEDV and LVESV), left ventricular ejection fraction(LVEF), left ventricular outflow tract pressure gradients(LVOT-PG), left atrial diameter(LAD), and mitral valve inflow and annular early diastolic velocity(E and e′). Besides, the carotid and cerebral arteries were involved including bilateral common carotid artery(CCA), internal carotid artery(ICA), middle cerebral artery(MCA), vertebral artery(VA), anterior cerebral artery(ACA), posterior cerebral artery(PCA), vertebral artery-intracranial(VA-IC) and basilar artery(BA). The ultrasound parameters of these arteries, such as peak systolic velocity(PSV), maximum end-diastolic velocity(EDV), average end-diastolic velocity(MDV), pulsative index(PI), resistance index(RI), velocity-time integrals(VTI), S/D, mean velocity(Mean) were all measured and compared.
Results〖HTSS〗The ratios of MLVWT, LVOT-PG, LAD, and E/e′ in the HCM group were significantly higher than those in the control group; EDV, MDV, and VTI of bilateral CCA were lower than those in the control group, and PI and RI were higher. PSV, EDV and MDV in right ICA were lower than those in the control group, PI and RI were higher.  EDV in left ICA was lower than that in the control group, PI and RI were higher. PI and RI of the right VA were higher than the control group. EDV in left VA was lower than that in normal control group, PI and RI were higher. RI and Mean in left MCA were higher than that of the control group. VTI of bilateral PCA and left ACA  were higher than that of the control group; PSV, PI, RI and SD of right va-ic were higher than that of the control group, the differences were statistically significant(P＜0.05).
Conclusion〖HTSS〗In addition to cardiac dysfunction, abnormal hemodynamic changes of carotid and cerebral arteries may also occurr in HCM. Therefore, carotid and cerebral vascular ultrasound should be performed routinely in HCM, which is of great significance for comprehensive clinical evaluation and early intervention.

Key words: cardiomyopathy, hypertrophic, hemodynamics, ultrasonography, Doppler, color