Abstract: ［Abstract］ObjectiveTo analyze the effects of Gabexate mesilate combined with continuous blood purification(CBP) on severe acute pancreatitis(SAP) and its influence on related factors of inflammation “cascade effect”.
〖WTHZ〗MethodsA total of 60 SAP patients were divided into observation group and control group according to the completely random method. Control group was given CBP, and observation group was combined with Gabexate mesilate. The efficacy, clinical treatment, inflammation “cascade effect” related factors ［tumor necrosis factor α(TNF-α), soluble tumor necrosis factor receptor(sTNFR), nuclear factor-κB(NF-κB), interleukin-6(IL-6), interleukin-8(IL-8)］ and incidence rate of complications were compared between two groups.
〖WTHZ〗ResultsThere were no significant differences in the total effective rate, 28 d mortality rate and incidence rate of complications between two groups(P＞0.05). However, the cure rate in observation group was significantly higher than that in control group, and the relief times of clinical symptoms and hospital stay were shorter than those in control group(P＜0.05). The related factors of inflammation “cascade effect” in two groups after treatment were significantly decreased compared with those at d1 time point, but the levels of related factors of inflammation “cascade effect” in observation group at d3-d7 time points were significantly lower than those in control group(P＜0.01). There was no significant difference of complication between two groups(P＞0.05).
〖WTHZ〗ConclusionGabexate mesilate on the basis of CBP in SAP patients can achieve better symptom relief, and more significantly improve the related factors of inflammation “cascade effect”, and it does not significantly increase the risk of complications. Thus it is worthy of clinical recommendation.

Key words: pancreatitis； gabexate mesylate, continuous blood purification