Abstract: ［Abstract］Objective〖HTSS〗To explore the relationship between ultrasound-guided cervical lymph node puncture combined with thyrotropin(TSH) and oluble interleukin-2 receptor(SIL-2R) and cervical lymph node metastasis and disease severity in patients with thyroid cancer.
 〖WTHZ〗Methods〖HTSS〗One hundred and twenty patients with thyroid cancer were selected and divided into stage Ⅰ/Ⅱ group and stage Ⅲ/Ⅳ group, non-metastatic group and metastatic group according to the postoperative pathological results. All patients underwent ultrasound-guided cervical lymph node aspiration and their serum TSH and SIL-2R levels were measured.
 〖WTHZ〗Results〖HTSS〗Ultrasound-guided cervical lymph node aspiration detected 106 lymph node metastases with an accuracy rate of 85.00%(102/120). The accuracy of ultrasound-guided cervical lymph node aspiration for stage Ⅱ, Ⅲ, and Ⅳ lymph node metastasis was significantly higher than that for stage thyroid cancer lymph node metastasis(P＜0.01). The levels of serum TSH and SIL-2R in stage Ⅲ/Ⅳ group were significantly higher than those in stage Ⅰ/Ⅱ group(P＜0.01). Serum TSH and SIL-2R levels were positively correlated with pathological stage in patients with thyroid cancer(P＜0.01). Serum TSH and SIL-2R levels in the metastatic group were significantly higher than those in the non-metastatic group(P＜0.01). For cervical lymph node metastasis of thyroid cancer, the accuracy, sensitivity, and negative predictive value of the combined ultrasound puncture, TSH, and SIL-2R parallel tests were significantly higher than those of the single test.
 〖WTHZ〗Conclusion〖HTSS〗Patients with stage Ⅲ/Ⅳ or thyroid cancer with cervical lymph node metastasis have higher serum TSH and SIL-2R levels. Ultrasound-guided cervical lymph node aspiration combined with serum TSH and SIL-2R detection can improve the accuracy and sensitivity of diagnosis.

Key words: thyroid neoplasms； punctures； thyrotropin, soluble interleukin-2 receptor