Abstract: ［Abstract］ Objective〖HTSS〗To analyze the changes of serum N-terminal pro-brain natriureticpeptide(NT-proBNP), C-reactive protein(CRP), interleukin-10(IL-10) and tumor necrosis factor-α(TNF-α) in children with sepsisand their relationship with prognosis.
〖WTHZ〗Methods〖HTSS〗Eighty children with sepsis(observation group) and 30 healthy children(control group) were enrolled in the study. Levels of serum NT-proBNP, CRP, IL-10 and TNF-α were compared between two groups within 5 days after admission. Above indicators in children with sepsis in different conditions were analyzed. According to the 28-dayprognosis of children with sepsis, they were divided into the good prognosis group and the poor prognosis group. Levels of serum NT-proBNP, CRP, IL-10 and TNF-α were compared between two groups within 5 days after admission. The predictive value of NT-proBNP, CRP, IL-10 and TNF-α levels for death of children with sepsis was analyzed.
〖WTHZ〗Results〖HTSS〗The serum levels of NT proBNP, CRP and TNF-α in the observation group increased first and then decreased from the first day to the fifth day after admission, while the serum levels of NT proBNP, CRP and TNF-α in the observation group were higher than those in the control group, while the serum levels of IL-10 were lower than those in the control group(P＜0.05). The mean NT proBNP, CRP and TNF-α of septic shock children were higher than those of general sepsis and severe sepsis children in 5 days after admission, while IL-10 was lower than those of general sepsis and severe sepsis children(P＜0.05). The average levels of NT proBNP, CRP and TNF-α in the patients with good prognosis were lower than those in the patients with poor prognosis, while IL-10 was higher than those in the patients with poor prognosis(P＜0.05). The area under ROC curve predicted by NT proBNP was 0.868, which was larger than that of CRP, IL-10 and TNF-α.
〖WTHZ〗Conclusion〖HTSS〗The levels of NT proBNP, CRP, IL-10 and TNF-α in children with sepsis were significantly changed within 5 days after admission, and they were closely related to the prognosis and should be monitored.

Key words: sepsis, brain natriuretic peptide, C-reactive protein