Abstract: Objective To investigate the diagnostic value of phase contrast magnetic resonance imaging(PCMRI) combined with serum placental growth factor(PlGF) and lactate dehydrogenase(LDH) on the reversible posterior leukoencephalopathy syndrome(RPLS).
Methods A total of 110 patients with preeclampsia(PE) in our hospital were selected as the study objects. All patients were scanned with conventional MR according to the results of conventional MRI, the patients were divided into two groups: normal group and RPLS group. At the same time, PCMRI was used to measure the hemodynamic parameters of basilar artery, and enzyme-linked immunosorbent assay(ELISA) was used, The level of PLGF and LDH in serum of the two groups were measured by ELISA, and the differences of laboratory test results, parameters of basilar artery hemodynamics, values of PLGF and LDH in serum were compared. The diagnostic value of basilar artery hemodynamics parameters combined with serum PlGF and LDH in PE patients with RPLS was determined by drawing ROC curve.
Results No obvious lesions were found in the normal group. The results of conventional MRI in RPLS group showed that T1WI was slightly low signal or equal signal, T2WI and flair were high signal, and DWI sequence was slightly low signal or equal signal. The MF, MV and vascular cross-sectional area of BA in RPLS group were significantly higher than those in MRI group, while RI was significantly lower than that in MRI group(P＜0.01). In RPLS group, PLGF water was significantly lower than that in MRI normal group, and LDH was significantly higher than that in MRI normal group(P＜0.01). Spearman correlation analysis showed that BAMV, MF and LDH were positively correlated with SBE(r=0.71,0.67, 0.68， P＜0.01 ）, RI was negatively correlated with SBE score(r=- 0.65， P＜0.01 ）。 The area under the curve of pcmri blood flow parameters combined with vascular endothelial damage markers in the diagnosis of RPLS was zero point eight nine seven （95%CI：0.853-0.941）The corresponding sensitivity and specificity were 93.0%, 100.0%, which was obviously better than the independent detection of each index.
Conclusion The BA blood flow parameters of RPLS and the changes of serum PlGF and LDH are closely related to the occurrence and development of the disease and the severity of brain edema. Imaging examination combined with serum index detection can improve the diagnostic specificity of the disease.

Key words: eclampsia, posterior leukoencephalopathy syndrome, phase contrast magnetic resonance imaging