Journal of Hebei Medical University

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A randomized controlled clinical study of platelet-rich autogenous plasma in promoting the recovery of median nerve function after decompression of carpal tunnel syndrome

  

  1. 1.Department of Orthopedics, the First Hospital of Hebei Medical University, Shijiazhuang  050031,
    China; 2.Department of Pathogen Biology, Hebei Medical University, Shijiazhuang 050017, China;
    3.Emergency Department, Dingxing County Hospital, Hebei Province, Baoding 072650, China;
    4.Department of Pharmacy, Baoding Fifth Hospital, Hebei Province, Dingxing 071027, China
  • Online:2020-07-25 Published:2020-07-28

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Abstract: Objective〖HTSS〗To study the effect of autologous platelet-rich plasma(PRP) on the recovery of median nerve function after decompression for carpal tunnel syndrome.
〖WTHZ〗Methods〖HTSS〗Forty patients with carpal tunnel syndrome were selected. According to the random number table method, they were randomly divided into control group and PRP injection group with 20 cases. The control group received carpal tunnel decompression. PRP injection group received peripheral injection of PRP after carpal tunnel decompression.The recovery of sensation, muscle strength and EMG of the two groups were compared.
〖WTHZ〗Results〖HTSS〗Thirty-one patients were followed up, with 4 patients lost to follow-up in the control group and 5 patients lost to follow-up in the PRP injection group. Patients in both groups were followed up for more than 12 months. VAS score, muscle strength grading, median nerve SNCV and MNCV showed statistically significant differences between  two groups at 1, 3, 6 and 12 months after surgery(P＜0.01).
〖WTHZ〗Conclusion〖HTSS〗PRP can promote the recovery of median nerve function after carpal tunnel decompression.

Key words: carpal tunnel syndrome, median nerve, platelet-rich plasma