Abstract: Objective  To investigate the effect of transverse bone transfer technique combined with platelet-rich plasma（PRP） in the treatment of diabetic foot and its effect on serum factors.
Methods  Eighty patients with diabetic foot were chosen and divided into treatment group and control group, 40 cases in each group. The control group was treated with PRP topical wound after debridement, the treatment group was treated with PRP external wound combined with transverse tibial bone transport. The treatment effects between the two groups were compared. And venous blood was extracted before and after treatment to monitor the improvement of patients epidermal growth factor(EGF), vascular endothelial growth factor(VEGF), basic fibroblast growth factor(bFGF), platelet derived growth factor(PDGF) and calcitonin gene-related peptide(CGRP).
Results  The total effective rate was 90.00% in the treatment group and 67.50% in the control group, the difference in the total effective rate between two groups was statistically significant(P＜0.05). After treatment, the detection values of EGF, VEGF, bFGF, PDGF and CGRP in both groups were improved, and the improvement degree in the treatment group was greater than that in the control group(P＜0.01).
Conclusion  The transverse bone transfer technique combined with PRP has a significant effect on the treatment of diabetic foot, which can effectively improve the serum levels of EGF, VEGF, bFGF, PDGF and CGRP.

Key words: diabetic foot, platelet-rich plasma； serum factor