Abstract: Objective  To investigate the effect of ulinastatin combined with Danhong injection on the level of soluble triggering receptor exprssed on myeloid cells-1(STREM-1) and heparin-bindingprotein(HBP), T help cell 17(Th17)/T regular cell(Treg) and clinical efficacy in sepsis patients.
Methods  A total of 120 patients with sepsis were selected and divided into control group and observation group according to the method of random number table, 60 cases each. The control group was treated with routine method combined with ulinastatin, and the observation group was injected with Danhong injection on the basis of the control group. The clinical efficacy of the two groups after treatment, Acute Physiology and Chronic Health Evaluation Ⅱ(APACHEⅡ) score, serum HBP and sTREM-1 levels, T cell subsets, coagulation function indexes and adverse reactions were compared before and after treatment.
Results  After 7 d of treatment, the effective rate of the observation group was 90.00%(54/60), which was significantly higher than that of the control group 75.00%(45/60), and the difference was statistically significant(χ2=4.490, P=0.034). There were significant differences in APACHEⅡ scores between two groups at different time points(P＜0.05). The serum HBP and sTREM-1 levels in two groups were lower than before treatment(P＜0.05), and the serum HBP and sTREM-1 levels in the observation group were significantly lower than those in the control group(P＜0.05 or P＜0.01). The expression rate of Th17 and Treg（CD4+CD25+, CD4+CD25high） in the two groups was significantly lower than that before treatment(P＜0.05). The expression rate of Th17 and Treg(CD4+CD25+, CD4+CD25high) in the observation group was significantly lower than that in the control group(P＜0.05 or P＜0.01). After treatment, platelet count(PLT) and fibrinogen(FIB) of two groups were increased, prothrombin time(PT), activated partial thromboplastin time(APTT) and thrombin time(TT) were decreased(P＜0.05); PLT and FIB of the observation group were significantly higher than those of control group, PT, APTT and TT were significantly decreased(P＜0.01). There was no significant difference in the incidence of adverse reactions between two groups(χ2=0.260, P=0.609).
Conclusion  Ulinastatin combined with Danhong injection has significant curative effect on sepsis patients. It can effectively regulate sTREM-1, HBP levels and Th17/Treg expression rate, improve immune and coagulation functions, and promote prognosis.

Key words: sepsis, ulinastatin, Danhong injection