Abstract: ［Abstract］Objective〖HTSS〗To evaulate the clinical efficacy of vacuum sealing drainage combined with Alprostadil and Apalstat in the treatment of diabetic foot ulcers(DFU).
〖WTHZ〗Methods〖HTSS〗Fifty-four patients with DFU were admitted to our research. According to random number table method, 27 cases were divided into control group and observation group. Routine treatment was adopted to both groups. Among them, patients in the control group were treated with vacuum sealing drainage combined with Alprostadil; patients in the observation group were treated with vacuum sealing drainage combined with Alprostadil and Apalstat. The reduction rate of wound,the cover rate of granulation tissue,the thickness of granulation tissue,the clearance rate of bacteria and the healing time of the wound were compared between two groups after treatment.
〖WTHZ〗Results〖HTSS〗In both groups the reduction rates of wound were increased significantly, and in observation group it was higher than that in the control group. And all of the difference between two groups at all time point were statistically significant(P＜0.01). The growth thickness, coverage rate and bacterial clearance rate of granulation tissue in the observation group were higher than those in the control group, and the difference was statistically significant(P＜0.01). The wound healing time of the observation group was lower than that of the control group(P＜0.01).
〖WTHZ〗Conclusion〖HTSS〗Vacuum sealing drainage combined with Alprostadil and Apalstat in the treatment of DFU patients has a significant effect and shortens the healing time of ulcers.

Key words: diabetic foot, ulcer, alprostadil, eapalst