Abstract: Objective  To analyze the related factors that affect the efficacy of noninvasive positive pressure ventilation(NPPV) in the treatment of sepsis-induced acute respiratory distress syndrome(ARDS).
Methods  A retrospective study was performed to collect the clinical data of 180 patients with sepsis-induced ARDS. All patients were treated with NPPV. Univariate analysis and multivariate Logistic regression analysis were used to analyze the related factors affecting the clinical efficacy.
Results  The treatment was effective in 153(85.00%) of 180 patients but ineffective in the remaining 27(15.00%). Compared with the ineffective treatment group, the platelet count of the effective treatment group was significantly increased, while the serum procalcitonin, C-reactive protein and sequential organ failure assessment(SOFA) score were significantly decreased(P＜0.05). Compared with the ineffective treatment group, the oxygenation index(arterial partial pressure of oxygen/arterial partial pressure of carbon dioxide, PaO2/FiO2) of the ineffective treatment group was increased significantly, while the proportion of the patients who converted to invasive positive pressure ventilation was decreased significantly(P＜0.05). Multivariate logistic regression analysis revealed that platelet count ＜50×109/L, PaO2 / FiO2＜150, and SOFA≥10 were independent risk factors for clinical efficacy.
Conclusion  Platelet count, PaO2/FiO2 and SOFA score are all related factors that affect the clinical efficacy of NPPV in the treatment of sepsis-induced ARDS.

Key words: respiratory distress syndrome, adult, sepsis, positive pressure ventilation