Abstract: Objective  To analyze the prediction value of myoglobin, creatine kinase(CK) and the myoglobin/CK ratio in acute renal failure(ARF) in patients with rhabdomyolysis syndrome(RM). 
Methods  The clinical data of 120 RM patients who were treated in People′s Hospital of Jiangsu Province and Pukou Hospital of Nanjing City were retrospective analyzed. Serum CK and myoglobin values and the myoglobin/CK ratio were compared between AKI patients and non-AKI patients, and classified into quartiles from the lowest to highest values. The incidence rate of AKI, mortality rate and the corresponding AKI distribution were calculated, and Spearman analysis was used to analyze the relevance between myoglobin, CK, and AKI. Univariate and multivariate Logistic regression analysis were used to explore the risk factors for predicting AKI. 
Results  A total of 47 cases(39.16%) of RM patients were complicated with AKI, of whom 42 patients were treated with hemodialysis. Of them, 2 patients died(death rate of 4.76%) and the remaining patients survived. Serum myoglobin concentration and CK activity in AKI patients were significantly higher than those in non-AKI patients(P＜0.05); Spearman analysis showed that the correlation coefficients of serum myoglobin concentration, serum CK activity and AKI were 0.51(P=0.003) and 0.22(P=0.019), respectively. Multivariate Logistic regression analysis showed that the serum myoglobin was a significant predictor of AKI, and the third and fourth quantiles of the myoglobin/CK ratio were all significant predictors of AKI(P＜0.05). 
Conclusion  Serum myoglobin and the myoglobin/CK ratio are significant risk factors for predicting AKI. Therefore, the test is recommended to be performed at admission. 

Key words: rhabdomyolysis, renal insufficiency, myoglobin, creatine kinase