Abstract: Objective  To investigate the diagnostic value of high-sensitive cardiac troponin T(hs-cTnT) in acutemyocardial infarction(AMI)in chronic renal failure(CRF) patients without dialysis. 
Methods  A total of 52 patients with chronic kidney disease stage 4(CKD stage 4)and without dialysis complicated with AMI(Group A) and 52 patients with CKD stage 4 and without dialysis(Group B) were enrolled in this study. The levels of hs-cTnT in the serum of the two groups at admission were compared, and the optimal diagnostic value for AMI in CKD stage 1 patients without dialysis was discussed. 
Results  The level of hs-cTnT was significantly higher in group A than in group B(P＜0.05). hs-cTnT was positively correlated with left atrium dimension(LAD),left ventricular end diastolic dimension(LVEDD)and left ventricular end systolic dimension(LVESD)(P＜0.01). In addition, hs-cTnT was negatively correlated with left ventricular ejection fraction(LVEF）and glomerular filtration rate(eGFR). LVEDD,LVEF and eGFR were the independent influencing factors of hs-cTnT level.The sensitivity and specificity of hs-cTnT in the diagnosis of AMI in CRF patients without dialysis was 75.00% and 90.38% respectively, with 72.50 ng/L as the cut-off value. 
Conclusion  For CRF patients without dialysis, increasing hs-cTnT cut-off value can effectively improve the specificity in AMI diagnosis. 

Key words: renal insufficiency, myocardial infarction, troponin T