Abstract: Objective  To analyze the value of combined detection of hypersensitive C-reactive protein(hs-CRP), homocysteine(Hcy) and blood coagulation function in evaluating the severity of acute cerebral infarction(ACI). 
Methods   A total of 106 patients with ACI were enrolled as the case group, and were divided into progression group(n=50) and non-progression group(n=56) according to presence or absence of progressive aggravation of the neurological symptoms within 96 hours of onset of the disease. In the meantime, 45 healthy persons who underwent physical examination were selected as control group. The serum hs-CRP, Hcy, lipid metabolism and blood coagulation function were compared in each group. 
Results  There were significant differences in serum hs-CRP, Hcy, lipid metabolism and blood coagulation function indexes in each group(P＜0.05). The levels of serum hs-CRP, Hcy, total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol(LDL-C), and D-dimer(DD) and fibrinogen(Fib) were significantly higher in the case group than in the control group(P＜0.05), while the level of high-density lipoprotein-cholesterol(HDL-C) was significantly lower in the case group than in the control group(P＜0.05). The levels of serum hs-CRP, Hcy, TC, TG, LDL-C, DD, and Fib in the progression group were significantly higher than those in the non-progression group(P＜0.05), whereas the level of HDL-C in the progression group was significantly lower than that in the non-progression group(P＜0.05). 
Conclusion  The patients with ACI may have obvious coagulation dysfunction and dyslipidemia. The levels of serum hs-CRP, Hcy, TC, TG, LDL-C, Fib and DD in patients with ACI in the progression group are remarkably increased, while the level of HDL-C is significantly decreased, which is of certain value in evaluating the severity of ACI.

Key words: infarction, C-reactive protein, homocysteine