Abstract:

Objective To explore the relationship of peripheral blood Chemerin with glucose and lipid metabolism, visceral fat, oxidative stress and inflammatory indexes in patients with diabetes mellitus(DM) complicated with metabolic associated fatty liver disease(MAFLD).

Methods A total of 84 DM patients(DM group), 124 DM patients with MAFLD(DM combined MAFLD group), and 62 healthy physical examinees(healthy control group) were selected. The peripheral blood Chemerin and its correlation with glucose and lipid metabolism, visceral fat, oxidative stress and inflammatory indexes among three groups were compared in the three groups. The predictive value of peripheral blood Chemerin in DM complicated with MAFLD was evaluated.

Results The levels of glucated haemoglobin A1c(HbA1c), fasting plasma glucose(FPG), 2 h plasma glucose(2 hPG), fasting insulin(FINS), homeostasis model assessment for insulin resistance(HOMA-IR), total cholesterol(TC), triacylglycerol(TG), Chemerin, high-sensitive C-reactive protein(hs-CRP), tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), visceral fat area（VFA） and malonaldehyde(MDA) in DM combined with MAFLD group were higher than those in control group and DM group, while the levels of high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), superoxide dismutase(SOD), and glutathione(CSH) were lower than those in the control group and DM group. The levels of HbA1c, FPG, 2 hPG, FINS, HOMA-IR, TC, TG, Chemerin, hs-CRP, TNF-α, IL-6, VFA and MDA were higher in the DM group than in the control group, while the levels of HDL-C, LDL-C, SOD and CSH were lower than those of the control group, and the differences were statistically significant(P＜0.05). Correlation analysis showed that Chemerin in peripheral blood was significantly positively correlated with TC, TG, Hs-CRP, TNF-α, IL-6, VFA and MDA(r=0.862, 0.784, 0.657, 0.835, 0.827, 0.857, 0.847, P＜0.01), and was significantly negatively correlated with HDL-C, LDL-C, SOD, and CSH(r=-0.300, -0.362, -0.513, -0.630, P＜0.01). Multiple stepwise regression analysis showed that TC, TG, IL-6, VFA and SOD were all influencing factors of Chemerin.

Conclusion Chemerin is closely related to IL-6, VFA and SOD, and is involved in the pathophysiological process of DM combined with MAFLD.

Key words: diabetes mellitus, fatty liver, Chemerin