Abstract:

Objective  To investigate the clinical efficacy of dense ligation combined with low-dose lauromacrogol injection in the treatment of gastroesophageal varices of patients with liver cirrhosis and portal hypertension.

Methods  A total of 110 liver cirrhosis patients with type 1 gastroesophageal varice(GOV1) were randomly divided into the control group(n=55) and the observation group(n=55). The control group was treated with spiral ligation combined with tissue glue injection, and the observation group was treated with dense ligation combined with lauromacrogol injection. The efficacy, the frequency of ligation, incidence of adverse reactions and recurrence rate of postoperative varices in the two groups were compared.

Results  The total effective rate of the initial treatment in the observation group was higher than that in the control group, the average frequency of ligation in the observation group was lower than that in the control group, and the incidence of postoperative rebleeding, postoperative pain, and postoperative adverse reactions including fever was lower in the observation group than in the control group, suggesting significant difference(P＜0.05). The recurrence rate of varices by gastroscopy was lower in the observation group than in the control group at 6 months and 12 months after completion of treatment, and the difference was statistically significant(P＜0.05); The difference was more significant with time.

Conclusion  Dense ligation combined with lauromacrogol injection is safe and effective in the treatment for GOV1, which can reduce the frequency of ligation, postoperative complications and recurrence rate of varices.

Key words: esophageal and gastric varices； dense ligation, lauromacrogol