Abstract: Objective To explore the expression of microRNA-205-5p(miR-205-5p), programmed cell necrosis factor 5(PDCD5), and Beclin1 in endometrial cancer tissues and their correlation. 
Methods In total, 75 cases of endometrial cancer tissues and adjacent tissues 5 cm away from the edge of the cancerous tissue of endometrial cancer were selected. The expressions of miR-205-5p, PDCD5, and Beclin1 were detected by immunohistochemistry and real-time fluorescence quantification methods, and the correlation of MiR-205-5p, PDCD5 and Beclin1 and their diagnostic value for endometrial cancer were analyzed. 
Results The expression of miR-205-5p in cancer tissues was higher than that in adjacent tissues, while the expression of PDCD5 and Beclin1 were lower than that in adjacent tissues(P＜0.05). The expressions of miR-205-5p, PDCD5 and Beclin1 in endometrial cancer patients with different histological grade, clinical stage, lymph node metastasis and muscle invasion were significantly different(P＜0.05). The expressions of miR-205-5p were increased in endometrial cancer patients with stage Ⅲ-Ⅳ, moderate-to-low differentiation, lymph node metastasis and muscle invasion≥1/2 , while the expression of PDCD5 and Beclin1 were decreased, and the difference was statistically significant(P＜0.05). There were no significant differences in the expressions of miR-205-5p, PDCD5 and Beclin1 in endometrial cancer patients with different ages and pathological types(P＞0.05). There was negative correlation between miR-205-5p and PDCD5, negative correlation between miR-205-5p and Beclin1, and positive correlation between PDCD5 and Beclin1(P＜0.05). The value of combined detection of the three in the diagnosis of endometrial cancer was higher than that of miR-205-5p, PDCD5 and Beclin1 alone(P＜0.05). 
Conclusion The increased expression of miR-205-5p and the decreased expression of PDCD5 and Beclin1 promote the development of endometrial cancer and participate in the evolution of endometrial cancer. The endometrial cancer can be predicted in clinical practice according to the above indicators.

Key words: endometrial neoplasms, microRNA-205-5p, programmed cell necrosis factor 5, Beclin1