Abstract: Objective To investigate the effects of goals-activity-motor enrichment (GAME) therapy combined with postural control on motor function in children with severe cerebral palsy (CP), and to provide evidence-based medical basis for improving motor function in children with severe CP. 
Methods In this prospective case-control study, 92 children with severe CP were included and randomly divided into research group (n=46) and conventional treatment group (n=46) according to random number table. The research group was treated with GAME therapy combined with postural control training, while the conventional treatment group was treated with neurodevelopmental therapy. Supine and prone position (area A) and sitting position(area B) in Gross Motor Function Measure-88 (GMFM-88), eye tracking (area A) and upper limb joint activity (area B) in Fine Motor Function Measure (FMFM), Level of Sitting Scale (LSS),Face-Legs-Activity-Cry-Consolability (FLACC) and Activities of Daily Living (ADL) scores were compared before treatment, and at 6 months and 12 months after treatment. 
Results The scores of GMFM-88 (area A and area B), FMFM (areaA andarea B), LSS and ADL in the two groups were gradually increased, while the scores of FLACC were gradually decreased. The scores of GMFM-88 (area A and area B), FMFM (area A andarea B), LSS and ADL in the research group were higher than those in the conventional treatment group, while FLACC scores were lower than those of conventional treatment group; the difference of interaction between groups, time points and time points between groups was statistically significant (P＜0.05). 
Conclusion GAME therapy combined with postural control can improve gross motor function, sitting ability and fine motor function,relieve pain and improve the ADL in children with severe CP. 

Key words: cerebral palsy, goals-activity-motor-enrichment therapy, posture control