Abstract: Objective To explore the detection and clinical significance of serum angiotensin converting enzyme 2 (ACE2) and macrophage migration inhibitory factor (MIF) in patients with hyperlipidemic pancreatitis. 
Methods The medical records of 86 patients with hyperlipidemic acute pancreatitis (HLAP) admitted to our hospital were retrospectively analyzed. According to the results of the three-month review, they were divided into a good prognosis group and a poor prognosis group. The relevant factors affecting the prognosis of hyperlipidemic pancreatitis were analyzed. The predictive value of serum ACE2 and MIF levels on the prognosis HLAP was evaluated by the area under the receiver operator characteristic (ROC) curve (AUC). 
Results Balthazar′s CT grade D, serum levels of MIF, triacylglycerol (TG) and low density lipoprotein cholesterol (LDL-C) were higher in the poor prognosis group than those in the good prognosis group, while the levels of ACE2 and high density lipoprotein cholesterol (HDL-C) were lower than those in the good prognosis group (P＜0.05). Multivariate Logistic regression analysis showed that the proportion of Balthazar′s CT grade D, the increase of serum MIF, TG, LDL-C expression and the decrease of ACE2, HDL-C expression were risk factors for poor prognosis of HLAP (P＜0.05). ROC analysis showed that the AUC of serum ACE2 and MIF alone and in combination in predicting the prognosis of HLAP was 0.754 (95%CI: 0.681-0.827), 0.759 (95%CI: 0.691-0.828) and 0.827 (95%CI: 0.785-0.867), respectively. 
Conclusion Both the increase of serum MIF expression level and the decrease of serum ACE2 level are related to the prognosis of patients with HLAP, and both of them are effective in predicting the prognosis of HLAP.

Key words: pancreatitis, angiotensin converting enzyme 2, macrophage migration inhibitory factor, prognostic analysis