Abstract: Objective To investigate the correlation between viral load of infantile cytomegalovirus(CMV) hepatitis(CMV) and γ-glutamyltransferase(γ-GGT) and its predictive value for prognosis. 
Methods A total of 163 children with CMV hepatitis admitted to the hospital were selected as the research subjects. The basic data of the children were collected, and the prognosis of the children was calculated at 6-month follow-up after admission. The correlation between viral load and γ-GGT in children with CMV hepatitis , and factors affecting the short-term prognosis of children with CMV hepatitis were analyzed. The value of viral load of CMV and γ-GGT in predicting the short-term prognosis of children with CMV hepatitis was analyzed. 
Results Pearson correlation analysis showed that CMV-DNA viral load was positively correlated with γ-GGT level in children with CMV hepatitis(P＜0.05). During the follow-up period of 163 children with CMV hepatitis, 27 had poor prognosis and 136 had good prognosis. Logistic multivariate regression analysis showed that CD4+/CD8+(OR:6.019, 95%CI:2.477-14.629), γ-GGT(OR:4.486, 95%CI:1.846-10.903), and CMV-DNA load(OR:5.859, 95%CI:2.411-14.240) were risk factors for the short-term prognosis of children with CMV hepatitis(P＜0.05). The results of ROC curve analysis showed that the sensitivity of CMV-DNA load and γ-GGT in predicting the short-term prognosis of children with CMV hepatitis was 77.78%(95%CI:57.27-90.62), 74.07%(95%CI:53.41-88.13), and 74.07%(95%CI:53.41-88.13), respectively; The specificity was 79.41%(95%CI:71.45-85.67), 77.21%(95%CI:69.07-83.77), and 90.44%(95%CI:83.90-94.61), respectively, and AUC was 0.766(95%CI:0.671-0.862), 0.758(95%CI:0.656-0.861), and 0.898(95%CI:0.835-0.962) respectively. 
Conclusion The viral load of children with CMV hepatitis is related to the level of γ-GGT, and CMV viral load and γ-GGT may affect the prognosis of children. The combination of the two has a good effect in predicting the prognosis of children with CMV hepatitis.

Key words: infantile cytomegalovirus, hepatitis, viral load, γ-glutamyltransferase, prognosis