Abstract: Objective  To analyze the correlation between DNA methyltransferase 3B (DNMT3B), forkhead box protein C1 (FOXC1) and ultrasonic characteristics of cervical cancer, in order to provide more means for clinical diagnosis of cervical cancer. 
Methods  A total of 117 patients with cervical cancer admitted to our hospital (research group) and 50 healthy physical examinees (control group) during the same period were selected as the research subjects. The expression of DNMT3B and FOXC1 was detected, and the relationship of DNMT3B and FOXC1 with Adler rade of color Doppler ultrasound parameters and the clinical characteristics of patients was analyzed. The clinical significance of DNMT3B and FOXC1 in cervical cancer was explored. 
Results  DNMT3B and FOXC1 in the research group were higher than those in the control group, which were positively correlated with Adler grade, carbohydrate antigen 125 (CA125), and carbohydrate antigen 199 (CA199) (P＜0.05). DNMT3B was associated with tumor size, high-risk human papillomavirus (HR-HPV) (-/+), lymph node metastasis and international federation of gynecology and obstetrics (FIGO) stage. FOXC1 was related to tumor differentiation and FIGO stage. 
Conclusion  DNMT3B and FOXC1 expression in cervical cancer is related to results of  dynamic ultrasound for cervical cancer. DNMT3B and FOXC1 expression levels in cervical cancer patients increase with the increase of Adler grade, and DNMT3B and FOXC1 are positively correlated with CA125 and CA199 expression, suggesting that DNMT3B and FOXC1 expression has certain value in the diagnosis of cervical cancer.

Key words: uterine cervical neoplasms, ultrasonography, DNA methyltransferase 3B, forkhead box protein C1