Abstract: Objective To observe the efficacy of low molecular weight heparin sodium in the treatment of intrahepatic cholestasis of pregnancy (ICP). 
Methods A total of 182 pregnant women with ICP admitted to our hospital were selected as the research subjects. They were randomly divided into control group (91 cases treated with ursodeoxycholic acid) and research group (91 cases treated with low molecular weight heparin sodium on the basis of control group). The clinical effects of two groups of pregnant women were compared and analyzed. The levels of prothrombin time (PT), fibrinogen (FIB), tissue-type plasminogen activator (t-PA), total bile acid (TBA), total bilirubin (TBIL) and alanine transaminase (ALT) were statistically analyzed before and after treatment. The pregnancy outcomes of pregnant women and newborns in two groups were compared and analyzed. 
Results After treatment, the total effective rate of the research group was significantly higher than that of the control group (P＜0.05). After treatment, PT and t-PA in the research group were higher than those in the control group, and the levels of FIB, TBA, TBIL and ALT in the research group were lower than those in the control group (P＜0.05). The delivery weeks of pregnant women in the research group were longer than those in the control group (P＜0.05). The cesarean section rate and postpartum hemorrhage rate in the research group were lower than those in the control group, while the vaginal delivery rate was higher than that in the control group (all P＜0.05). The 5-min Apgar score of newborns in the research group was higher than that in the control group (P＜0.05). The premature birth rate, neonatal asphyxia rate and intrauterine distress rate in the research group were lower than those in the control group (P＜0.05). 
Conclusion Low molecular weight heparin sodium is effective in the treatment of ICP. It can not only improve the coagulation function and liver function of pregnant women, but also prolong the pregnancy time, reduce the rate of cesarean section and preterm delivery. 

Key words: cholestasis, intrahepatic, pregnancy, low molecular weight heparin sodium