Abstract: Objective To explore the expression of β-cell trophic factor (Betatrophin) and nuclear factor-κB (NF-κB) in patients with polycystic ovary syndrome (PCOS) and their predictive value for pregnancy outcome. 
Methods A total of 110 patients with PCOS were selected as the research subjects, and 40 healthy women of childbearing age who underwent physical examinations during the same period were selected as the control group. The related serum indexes of the two groups were compared. Risk factors for pregnancy was analyzed, and the predictive value of combined detection of Betatrophin and NF-κB for pregnancy outcomes after treatment was evaluated. 
Results Before treatment, the levels of serum fasting blood glucose(FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistance(HOMA-IR), homeostatic model assessment β cell function (HOMA-β), luteinizing hormone (LH), LH/follicle stimulating hormone (FSH), anti-mullerian hormone (AMH), NF-κB and Betatrophin in PCOS patients were higher than those in the control group (P＜0.05), which were reduced after treatment. At 1-year follow-up, the ovulation rate of PCOS patients was 77.27%, and the pregnancy rate was 61.82%. Multivariate Logistic regression analysis showed that HOMA-IR, HOMA-β, LH/FSH, AMH, Betatrophin, and NF-κB were risk factors for pregnancy success, and that Betatrophin was positively correlated with HOMA-IR, HOMA-β, LH/FSH, and AMH after treatment (P＜0.05). NF-κB was also positively correlated with FBG, HOMA-IR, LH/FSH, and AMH (P＜0.05). The receiver operating characteristic (ROC) curve showed that the area under the ROC curve (AUC) of combined detection of Betatrophin and NF-κB in predicting the pregnancy outcome after PCOS treatment was 0.978 (0.961-0.998), the sensitivity was 86.75%, and the specificity was 90.12%. 
Conclusion The levels of Betatrophin and NF-κB are increased in PCOS patients and significantly decreased after treatment. The serum levels of the two were positively correlated with HOMA-IR, LH/FSH, and AMH. The combined detection of Betatrophin and NF-κB has certain predictive value for pregnancy outcomes of patients with PCOS.

Key words: polycystic ovary syndrome, β cytotrophic factor, nuclear factor- κB