Journal of Hebei Medical University ›› 2025, Vol. 46 ›› Issue (8): 875-880.doi: 10.3969/j.issn.1007-3205.2025.08.002

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Predictive effectiveness of serum TK-1 combined with Hsp90α for curative effect of high-intensity focused ultrasound ablation in liver cancer

  

  1. Department of Hepatobiliary Surgery, the People′s Hospital of Shijiazhuang City, Hebei Province, Shijiazhuang 050011, China

  • Online:2025-08-25 Published:2025-08-29

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Abstract:

Objective To explore the predictive effectiveness of serum thymidine kinase 1 (TK-1) combined with heat shock protein 90α (Hsp90α) for curative effect of high-intensity focused ultrasound (HIFU) ablation in liver cancer. 

Methods A total of 150 patients with liver cancer undergoing HIFU ablation in the hospital between May 2022 and October 2024 were enrolled. According to different curative effect, they were divided into complete ablation group (n=120) and residual group (n=30). The levels of serum TK-1, Hsp90α and alpha-fetoprotein (AFP) in the two groups were detected and compared before surgery. The predictive effectiveness of the three indexes detected alone or in combination for curative effect of HIFU ablation in liver cancer was analyzed by receiver operating characteristic (ROC) curves, and influencing factors of the curative effect were analyzed by multivariate Logistic regression analysis. 
Results The levels of serum TK-1, Hsp90α and AFP in residual group were higher than those in complete ablation group ［(5.50±1.11) pmol/L vs. (4.28±0.95) pmol/L, (134.28±14.22) μg/L vs. (116.60±13.78) μg/L, (42.17±10.93) μg/L vs. (29.56±9.65) μg/L; P＜0.05］. There was significant difference in China Liver Cancer Staging (CNLC) between the two groups (P＜0.05). ROC curve analysis showed that area under the curve (AUC) of serum TK-1 combined with Hsp90α for predicting the curative effect of HIFU ablation was 0.912 ［95%CI: 0.851-0.974］, which was greater than that of single index or AFP (TK-1: 0.791, Hsp90α: 0.802, AFP: 0.799). AUC of TK-1 combined with Hsp90α and AFP for predicting the curative effect was 0.925 ［95%CI: 0.876-0.974］, which was greater than that of single index (Tk-1:0.791, Hsp90α : 0.802, AFP: 0.799). Multivariate Logistic regression analysis showed that CNLC stage Ⅰb (OR=2.004, P=0.001), TK-1＞5.09 pmol/L (OR=2.492, P＜0.001) and Hsp90α >125.00 μg/L (OR=2.509, P＜0.001) were independent risk factors affecting curative effect of HIFU ablation. 
Conclusion Serum TK-1, Hsp90α and AFP all can predict the curative effect of HIFU ablation in liver cancer, and predictive effectiveness of serum TK-1 combined with Hsp90α is higher than that of AFP. 

Key words: liver neoplasms, thymidine kinase 1, heat shock protein 90α