Abstract: [
Abstract ] Objective Toinvestigatetheexpressionandsignificanceofglypican-3 ( GPC-3 ) in
prostatecancer.Methods Atotalof30casesofprostatecancertissuesand30casesofbenign
prostatichyperplasiatissues wereincludedinthestudy withtheimmunohistochemicalS-P
methodtodetecttheexpressionofGPC-3inprostatecancerandbenignprostatichyperplasia.
Results ThepositiveratesofGPC-3expressioninprostatecancertissueswassignificantlyhigher
thanthatin benign prostatichyperplasiatissues ( P <0.05 ) .Thepositiveratesof GPC-3
expressioninprostatecancertissueswithgleasonscoreequaltoormorethan7wassignificantly
higherthanthatwithgleasonscorelessthan7 ( P <0.05 ) .Conclusion HighexpressionofGPC-
3inprostatecancermayplayanimportantroleindevelopmentofprostatecancer.

Key words: prostaticneoplasms , prostatichyperplasia , glypicans