Abstract: ［Abstract］ Objective〖HTSS〗〓Use of tranexamic acid can reduce perioperative blood loss and decrease the rate of transfusion in the intraoperative and postoperative lumbar spine surgery. To analysis the effects of tranexamic acid on lumbar spine surgery blood loss and transfusion rate by comparing differences among the preoperative intravenous application group, simple application in the wound group and blank control group.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 120 patients performed lumbar posterior more than triarticular open operation were divided into 3 groups randomly, 40 patients in each group. Patients with topical application of tranexamic acid in the wound among surgery were belong to group A, patients with intravenous application of tranexamic acid at half an hour before surgery were belong to group B, and patients with no tranexamic acid were belong to group C. Some indicators will be observed, such as time of operation, intraoperative blood loss, postoperative blood loss in 48 hours, condition of the blood transfusion and complication, etc.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The postoperative incisions of patients in 3 groups were primary healing. There were no significant differences in 3 groups about the time of operation（P＞005）. The amount of postoperative blood loss in 48 hours in group A and B was less than it in group C（P＜005）.Compared to group C, the per capita amount of blood transfusion in group A and B was decreased（P＜005）, and the amount in group A was less than it in group B（P＜005）. The number of patients with transfusion in group A and B was less than it in group C, and the difference was statistically significant（P＜005）.There were no significant differences in the incidence of complications among 3 groups（P＞005）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓In the lumbar spine surgery, tranexamic acid can reduced the hidden blood loss, intraoperative and postoperative blood loss and blood transfusion rate.

Key words: lumber vertebrae, blood loss, surgical, tranexamic acid