Abstract: ［Abstract］ Objective〖HTSS〗〓To evaluate the effect of radiotherapy combined targeted therapy.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A retrospective analysis was performed on the medical records of 91 cases with locally advanced nonsmall cell lung cancer(NSCLC). The pathology was confirmed via histology and cytology, using three dimensional conformal radiation therapy or intensitymodulated radiation therapy, with 1.8-2.0 Gy per fraction once a day, five times a week and planning target volume 56-64 Gy. Thirtynine received radiotherapy alone. And 52 received radiotherapy combined with erlotinib. The KaplanMeier method was used to calculate overall survival rate. The Cox regression model was used for multivariate prognostic analysis.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓For all the patients, the survival rate of one, two and three years were 63.4%, 33.8%, and 17.0% respectively, and the median survival time was 19.4 months. Univariate analysis by Logrank test showed that the progress free survival and overall survival time varied significantly among lung cancer patients from different pathology type, gross target volume（GTV）, irradiation dose and epidermal growth factor rececptor（EGFR） mutation or nonmutation and receiving target therapy or nonreceiving target therapy(P＜005)，according to this research it indicated that lung cancer patient with squamous cell carcinoma, GTV less than 250 cm3, irradiation dose more than 60 Gy, EGFR mutation and receiving target therapy could survive a longer progress free survival and overall survival. Multiple factors analysis of Cox regression model suggested radiation dose, targeted therapy, the curative effect were the main factors for patients' survival time(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Radiation dose, target treatment and curative effect were prognostic factors of locally advanced NSCLC. Radiotherapy combined targeted therapy was an effective method for locally advanced NSCLC.

Key words: carcinoma, nonsmall cell lung；chemo radiotherapy; , prognosis