Abstract: ［Abstract］  ObjectiveTo discuss the clinical efficacy and safely of the Qswitched 1 064 nm laser combined with  free and Xiaoyao Pill in the treatment of chloasma. MethodsForty cases patients with chloasma were randomly divided into two groups. The treatment group(20 cases) was given Qswitched 1 064 nm laser combined with free and Xiaoyao Pill treatment. The control group(20 cases) was given a simple Qswitched 1 064 nm laser treatment. The skin melanin/erythema/wrinkle index were measured with a skin evaluation instrument before and after each treatment. ResultsAfter  treatment， 2 groups of  melanin index, erythema index, wrinkle index decreased gradually. The treatment group was lower than the control group. There was significant difference in interaction between different groups, different time points and between different time points of groups(P＜005). ConclusionThe Qswitched 1 064 nm laser combined with free and Xiaoyao Pill on chloasma is a safe and effective and not easy to relapse.

Key words: chloasma, laser therapy, Xiaoyao pill