Abstract: ［Abstract］〓Objective〖HTSS〗〓To observe the clinical efficacy of ranibizumab combined with 577 nm laser photocoagulation for severe nonproliferative diabetic retinopathy with macular edema.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓 Sixty patients and 60 eyes with severe nonproliferative diabetic retinopathy with macular edema were randomly divided into observation group and control group, 30 cases and 30 eyes respectively. The observation group was given ranibizumab in combination with 577 nm laser photocoagulation, and the control group was given 577 nm laser photocoagulation. Optical coherence tomography and fluorescein fundus angiography were reexamined 1 week, 1 month, 3 months and 6 months after treatment. The best corrected visual acuity before and after treatment, the thickness of the foveal retinal neuroepithelial foci of the macula and the total volume of the neuroepithelial lesion of the 6 mm diameter in the macular area were recorded and compared. The laser energy, energy density, number of spots and complications were compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓With the extension of time, the best corrected visual acuity of two groups were significantly increased, the macular foveal retinal neuroepithelial thickness and macular area 6 mm diameter neuroepithelial overall volume of two groups were significantly decreased. The best corrected vision of observation group was higher than the control group, macular foveal retinal neuroepithelial thickness and macular area 6 mm diameter neuroepithelial overall volume were lower than the control group, There were significant differences in interaction among groups, time points and time points between groups（P＜005）. The laser energy, spot number and energy density of the observation group were lower than that of the control group （P＜005）. No serious complications occurred in either group. 〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The efficacy of ranibizumab combined with 577 nm laser photocoagulation for severe nonproliferative diabetic retinopathy with macular edema is positive and clinically safe.

Key words: diabetic retinopathy, macular edema, rayuzumab, laser therapy