Abstract: ［Abstract］  Objective〖HTSS〗〓To investigate the changes of liver function, blood routine and portal vein hemodynamics before and after embolization of hepatosplenic interventional therapy in patients with hepatocellular carcinoma complicated with hypersplenism.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 58 patients with hepatocellular carcinoma and hypersplenism were performed with dual interventional therapy of hepatic and splenic artery chemoembolization. The levels of leukocyte, platelet, alanine aminotransferase and bilirubin were detected in preoperative, on day 3 and one week after the dual interventional.
We also observed portal vein diameter and the flow peak time of portal vein blood before and after the embolization.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The platelet count and the white blood cell count of the patients observed in one week after the embolization were significantly higher than that in patients before and day 3 after the embolization（P＜0.05）. But the levels of alanine aminotransferase and bilirubin of the patients in one week after the interventional therapy were significantly lower than that in patients day 3 after the interventional therapy（P＜0.05）. The diameter of portal vein and the peak time of contrast medium had no significant difference before and after embolization(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The treatment of liver cancer complicated with hypersplenism by minimally invasive double interventional embolization not only weakens the function of spleen in destroying the blood cells, but also retains the normal immune function of some spleen, increased blood count. The treatment has the advantages of little damage to the liver function, quick recovery, reducing the infection opportunity of the patient, and ensuring the followup treatment of the patients with liver cancer, and has the safety and effectiveness. Minimally invasive Interventional embolization for hepatocellular carcinoma with hypersplenism, not only weakened the function of spleen destruction of blood cells, but also retained some of the normal immune function of the spleen, increased blood cell count, small damage to liver function, rapid recovery, reduced the chance of infection, guaranteed the followup treatment of liver cancer patients, has safety and effectiveness.

Key words: liver neoplasms, hypersplenism, chemoembolization, therapeutic