Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the expression of TGFβ1, Slug and Ecadherin in  cholangiocarcinoma tissues and their clinical significance.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Immunohistochemical SP method was used to detect the expression of TGFβ1, Slug and Ecadherin in 70 cases of cholangiocarcinoma and 20 cases of paratumor tissue. The clinical significance were analyzed. The correlation between expression of TGFβ1, Slug and Ecadherin was analyzed by Spearman analysis method.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive expression rates of TGFβ1, Slug and Ecadherin in cholangiocarcinoma tissue were significantly different from those in paratumor tissue（P＜005）. The positive expression rates of TGFβ1 and Slug were significantly higher in lymph node metastasis and hepatic artery or portal vein invasion patients than those in no lymph node metastasis（P<0.05）and hepatic artery or portal vein invasion patients(P＜005）. The positive expression rates of Ecadherin were significantly lower in lymph node metastasis and hepatic artery or portal vein invasion patients than those in no lymph node metastasis（P＜005）and hepatic artery or portal vein invasion patients(P＜005）. There was a positive correlation  between TGFβ1 and Slug expression in cholangiocarcinoma（rs=0.658, P=0000）. There were  negative correlations between TGFβ1 and Ecadherin（rs=-0.527, P=0000）. The expression of Slug was negatively correlated with the expression of Ecadherin（rs=-0.526, P=0000）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The abnormal expressions of TGFβ1, Slug and Ecadherin may play an important role in carcinogenesis and progression of cholangiocarcinoma.

Key words: bile duct neoplasms； , transforming growth factor beta 1, desmosomal cadherins