Abstract: ［Abstract］ Objective〖HTSS〗〓To observe the effect of remote ischemic preconditioning(RIPC) on the transient cerebral index and vascular function in patients with transient ischemic attack(TIA), and to investigate the protective effect and mechanism of RIPC on TIA.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Two hundred patients were randomly divided into treatment group and control group, with 100 patients of each group. The control group received only secondary prevention guidelines of stroke and transient ischemic attack in 2011. The treatment group was trained with RIPC on the basis of the control group. The cerebral blood flow indexes of the common carotid artery and middle cerebral artery were measured by TCD before and after treatment. Serum hypoxiainducible factor1α(HIF1α) and vascular endothelial growth factor(VEGF) levels were measured by enzyme linked immunosorbent assay.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Cerebral blood flow was increased in patients with RIPC training than that without training. HIF1α and VEGF levels were significantly decreased in patients with RIPC training than that without training, and the difference was statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓RIPC can increase cerebral blood flow and regulate serum HIF1α and VEGF levels of patients with TIA. It has good effect on prevention and treatment of TIA.

Key words: ischemic attack, transient, hypoxiainducible factor 1, alpha subunit, vascular endothelial growth factors