Abstract: ［Abstract］ Objective〖HTSS〗〓To compare the clinical efficacy of different doses danshen injection combined with pidotimod in the treatment of henoch schonlein purpura(HSP) .
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 152 cases of children with HSP admitted into pediatric department of Huangshi central hospital were randomly divided into three groups: pidotimod group(n=49), conventionaldose combination group(n=51) and large dose combination group(n=52). Three groups all were received conventional medical treatment, Pidotimod group accepted pidotimod 400 mg/d, conventionaldose combination group accepted Danshen injection 10 mL/d combined with pidotimod 400 mg/d, while the large dose group accepted Danshen injection 20 mL/d combined with pidotimod 400 mg/d. The treatment course lasted for 2 weeks. The clinical symptoms disappeared time, the recurrence rate after 6 months, peripheral blood immune function, oxidative stress parameters contents before and after the treatment and the clinical efficacy of 3 groups were recorded.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The clinical symptoms including purpura, abdominal pain, joint pain, skin rashes and kidney damage disappeared time of conventionaldose combination group and large dose combination group were lower than that of pidotimod group, that of large dose combination group was lower than that of conventionaldose combination group(P＜0.05). The recurrence rate of large dose combination group was significantly lower than that of other group by six months followup time(P＜005）. After treatment, the glutathione peroxidase, superoxide dismutase, CD3+, CD4+, CD8+ and CD4+/CD8+ of three groups were all improved, but large combination dose group was better than the other two groups, conventionaldose combination was better than the pidotimod groups(P＜0.05). The cure rate and total effective rate of pidotimod group was lower than that in conventionaldose combination group and large combination dose group, the conventionaldose combination group was lower than large combination dose group ,all the differences were statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Large dose danshen injection combined with pidotimod in the treatment of children with HSP can achieve a higher clinical efficacy, reduce the recurrence rate, and is safe and reliable, which is worthy of clinical application.

Key words: purpura, henochschonlein, Danshen injection, pidotimod, child