Abstract: Objective To observe and summarize the clinical effect of salmeterol xinafoate and fluticasone propionate aerosol combined with sublingual dust mite drops in children with dust mite allergic asthma.  
Methods A total of 85 children with dust mite allergic asthma who were admitted to our hospital were selected and divided into 2 groups by random number table method. The control group received salmeterol xinafoate and fluticasone propionate aerosol(n=42) and the observation group received salmeterol xinafoate and fluticasone propionate aerosol combined with sublingual immunotherapy with dust mite drops(n=43). The therapeutic effects of the two groups and the changes in clinical indicators before and after treatment were summarized, and incidence of adverse reactions during treatment was analyzed in two groups. 
Results After treatment, the total effective rate in the observation group was 93.02%(40/43), which was significantly higher than 76.19%(32/42) in the control group, and the difference was statistically significant(P＜0.05). After treatment, the improvement of serum dust mite specific immunoglobulin G(SIgG4) and serum interleukin(IL)-12 in the observation group was better than that in the control group, and the difference was statistically significant(P＜0.05). The daytime symptom score and nighttime symptom score of asthma in the observation group were lower than those in the control group after treatment, and the difference was statistically significant(P＜0.05). During the treatment period, there was mild throat pain in both groups, including 4 cases(9.30%) in the observation group and 3 cases(7.14%) in the control group, however, there was no statistically significant difference(χ2=0.131, P=0.717).  
Conclusion Salmeterol xinafoate and fluticasone propionate aerosol combined with sublingual immunotherapy with dust mite drops for children with dust mite allergic asthma is effective in ameliorating the asthma symptoms of children such as airway inflammation and immune imbalance. Therefore, it has good application value in clinical practice.

Key words: sthma, salmeterol xinafoate and fluticasone propionate aerosol, child