Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the predictive value of cystatin C(Cys C) on the prognosis in patients with acute ischemic stroke.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 264 consecutive patients admitted to the department of neurology, were recruited retrospectively. The clinical characteristics regarding the patients were recorded. Neurologic impairment was assessed based on the National Institutes of Health Stroke Scale(NIHSS). The patients were divided into favorable prognosis group(n=150) and poor prognosis group(n=114), according to the modified Rankin Scale(mRS). The differences of the general characteristics were compared between 2 groups. The multivariate logistic regression analysis was used to analyze the factors of poor prognosis of acute ischemic stroke. The serum Cys C levels in patients with different stroke severity were compared. The receiver operating characteristic curve was used to evaluate the predictive value of Cys C.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Age/the history of atrial fibrillation in patients and the history of ischemic stroke in patients with poor outcome were significantly higher than those in patients with favorable outcome. The level of serum Cys C and NIHSS score in the poor prognosis group were higher than those in the favorable prognosis. The degree of neurological impairment were positively correlated with the serum Cys C. The results of multivariate logistic regression analysis showed that increased NIHSS score, the level of Cys C and the history of atrial fibrillation in patients on admission were independent risk factors for poor prognosis. The optimal critical value of the level of Cys C on admission for the poor prognosis were 0.97. The sensitivity was 65.8%, while the specificity was 66.7%, while the acauracy was 66.0%.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The level of serum Cys C at admission has a good predictive value for the prognosis of patients with acute cerebral infarction. High serum Cys C level suggests poor prognosis.

Key words: brain infarction, cystatin C, prognosis, risk factors