Abstract: ［Abstract］〓Objective〖HTSS〗〓The purpose of this study is to analyze the etiology characteristics of severe pneumonia in nonHIV immunosuppressed patients.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 101 cases of nonHIV immunosuppressed patients with severe pneumonia in the intensive care unit. The etiology data(including sputum, lower respiratory tract secretion and alveolar lavage fluid, pathogens antibody examination, G test, blood culture and drug susceptibility test results) of these patients were retrospectively analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The 251 strains of pathogen were isolated from these patients. Thegramnegative bacilli were 184 strains(73.31%), including acinetobacter baumannii, pseudomonas aeruginosa, klebsiella pneumoniae and e. coli etc. The gram positive coccus were 5 strains(1.99%). Funguses were 62 strains(24.70%), including Candida albicansand Aspergillus. Pneumocystis was 8 cases(3.19%). Serological G test were positive in 54 cases(53.47%). Virus serological examination revealed cytomegalovirus(CMV) DNA copy were positive in 31 cases, CMV IgG antibody were positive in 3 cases. Epsteinbarr virus(EBV) DNA copy was increased in 23 cases, EBV IgG antibody were positive in1 cases. Herpes simplex virus type 1 IgG was positive in 3 cases, Herpes simplex virus type 2 IgG was positive in 2 cases, Rubella virus IgG was positive in 3 cases, respiratory syncytial virus IgM antibody was positive in 2 cases. Serum Mycobacterium tuberculosis antibody was positive in 9 cases. The 38 kDa protein antibody was positive in 7 cases, 16 kDa protein antibody was positive in 1 case, LAM antibody was positive in 8 cases. Blood culture of bacteria was positive in 11 cases, a total of 17 strains pathogens were isolated, mainly were aureus, including staphylococcus 7 cases, staphylococcus epidermidis 2 cases and staphylococcus haemolyticus 2 cases, and staphylococcus aureus, staphylococcus capitis, enterococcus faecium, acinetobacter baumannii were all 1 case separately. Drug sensitive test showed high multiple drug resistance in gram negative bacilli including acinetobacter baumannii, pseudomonas aeruginosa, and klebsiella pneumonia. But no grampositive cocci were founded to be resistant to vancomycin or linezolid.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Multiple drugresistant bacteria infection, fungi and viruses infection ratio were high in nonHIV immunosuppressed patients with severe pneumonia. And pneumocystis pneumoni should be vigilant also.

Key words: neumonia, human immunodeficiency virus, noxae