Abstract: Objective To investigate the drug resistance of pathogenic bacteria in neonatal ventilator-associated pneumonia ventilator associated pneumonia（VAP） and the effect of pathogenic bacteria on prognosis.
Methods Sixty-five neonates with ventilator-associated pneumonia hospitalized in our hospital were divided into VAP group and 65 neonates who were hospitalized with mechanical ventilation but not complicated with VAP were selected as non-VAP group. The culture of endotracheal secretions and drug sensitivity test in VAP group were used to analyze the infection and short-term prognosis of pathogenic bacteria.
Results Forty-nine strains of pathogenic bacteria were cultured from the secretion of 65 VAP newborns, and the results showed that all of them were Gram-negative bacteria. The proportion of species was 30.61% for Klebsiella pneumoniae, 28.57% for Escherichia coli, and 20.41% for Acinetobacter baumannii. The resistance of these three kinds of bacteria to cephalosporins and amikacin was 100% Antibiotics such as imipenem, ciprofloxacin are more sensitive. During intubation and every day after detection, the clinical pulmonary infection score of the two groups decreased gradually, and the VAP group was significantly higher than that of the non VAP group(P＜0.05); according to the results, the duration of mechanical ventilation, the length of hospitalization of NICU and the overall length of hospitalization in the VAP group were significantly longer than that in the non VAP group(P＜0.05), and the mortality of the former was significantly higher than that in the non VAP group(P＜0.05).
Conclusion VAP newborns with drug-resistant bacteria infection, children in the treatment of anti infection will have poor efficacy, mechanical ventilation and more time needed for hospitalization, and the mortality rate of children also showed an increasing trend. In the actual diagnosis and treatment, it is necessary to give sensitive antibiotics according to the test results, control the drug resistance of pathogenic bacteria to a certain extent, and improve the cure rate.

Key words: pneumonia, ventilator-related, infant, newborn, prognosis