Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze the clinicopatholocal features of pancreatic neuroendocrine neoplasms(PNENs) and investigate the treatment and prognosis in patients with pancreatic neuroendocrine tumor.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓According to the results of immunohistochemical examination, 47 cases of pancreatic neuroendocrine tumors were divided into functional group(11 cases) and nonfunctional group(36 cases). According to the nuclear fission image count and the Ki67 index, 40 cases were divided into the nuroendocrine tumor(NET) group and 7 cases were divided into the nuroendocrine carcinoma(NEC) group. The patients were followed up, and the case data, pathological data, treatment process and prognosis of the patients were analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There were no statistically significant differences in gender, clinical stage and tumor grade between functional groups and nonfunctional groups(P＞005). NET groups were all in Ⅰperiod and Ⅱ period, NEC group are distributed in each period. The difference between the 2 groups was statistically significant.(P＜005). There were no statistically significant differences in gender, CgA and Syn expression between the NET group and the NEC group(P＞005). Thirty patients were followed up, with a followup period of 4-68 months. One patient had liver metastasis and underwent microwave ablation until the end of the followup.  The survival condition was still good. The remaining 29 patients had no metastasis or recurrence and had a good survival.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Pancreatic neuroendocrine tumors can occur in all parts of the pancreas. CT or MRI is the main examination method, and the diagnosis depends on pathological diagnosis, and the treatment is mainly surgery, combined with targeted therapy, radiofrequency ablation, chemotherapy and other methods. The overall prognosis of pancreatic neuroendocrine neoplasms is good.

Key words: pancreatic neoplasms, pathology, clinical, prognosis